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Semiautomated ROI Analysis in Dynamic MRI-Studies, Part II: Application to Renal Function Examination, First Experiences

G.K. von Schulthess, W. Kuoni, G. Gerig, S. Duewell and G. Krestin
Journal of Computer Assisted Tomography
No. 5, pp. 733-741, 1991


Fast MRI techniques and the application of water-soluble contrast agents allow the simultaneous examination of renal morphology and the functional aspects of glomerular filtration using bolus injections of Gd-DTPA. Spatial resolution is sufficient to resolve individual renal pyramids, but the quantitative examination of regions of interest is severely impeded by organ movements due to variations of the end-inspiratory position. A new image processing scheme (preceding paper Part I) has been used and tested in 23 normal volunteers and patients. This scheme replaces a tedious frame by frame ROI analysis by positional correction of renal regions of all frames of the sequence such that the definition of the regions has to be performed only once. The signal intensities of the local regions in each frame are used to compute statistics and to generate curves representing local temporal signal intensity changes due to contrast agent excretion. The success rate of the procedure largely depends on the image quality and on the adherence to a proved acquisition protocol. The present paper shows, that the combination of MRI and robust and reliable image processing methods can be important for the highly automated analysis of a large number of images acquired as dynamic studies.

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  author = {G.K. von Schulthess and W. Kuoni and G. Gerig and S. Duewell and G. Krestin},
  title = {Semiautomated ROI Analysis in Dynamic MRI-Studies, Part II: Application to Renal Function Examination, First Experiences},
  journal = {Journal of Computer Assisted Tomography},
  year = {1991},
  month = {},
  pages = {733-741},
  volume = {},
  number = {5},
  keywords = {medical image analysis, model-based, recognition, MR imaging, interpretation}