This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.

Search for Publication

Year(s) from:  to 
Keywords (separated by spaces):

Inter-subject Modelling of Liver Deformation During Radiation Therapy

M. von Siebenthal, G. Székely, A. Lomax and Ph. Cattin
Medical Image Computing and Computer-Assisted Intervention MICCAI 2007


This paper presents a statistical model of the liver deformation that occurs in addition to the quasi-periodic respiratory motion. Having an elastic but still compact model of this variability is an important step towards accurate patient setup and reliable targeting in radiation therapy. To build this model, the deformation of the liver at exhalation was determined for 12 volunteers over roughly one hour using 4DMRI and subsequent non-rigid registration. The correspondence between subjects was established based on mechanically relevant landmarks on the liver surface. Leave-one-out experiments were performed to evaluate the accuracy in predicting the liver shape from partial information, such as a point tracked by ultrasound imaging. Already predictions from a single point strongly reduced the localisation errors, whilst the method is robust with respect to the exact choice of the measured predictor.

Download in pdf format
  author = {M. von Siebenthal and G. Székely and A. Lomax and Ph. Cattin},
  title = {Inter-subject Modelling of Liver Deformation During Radiation Therapy},
  booktitle = {Medical Image Computing and Computer-Assisted Intervention MICCAI 2007},
  year = {2007},
  pages = {659-666},
  volume = {4791},
  series = {LNCS},
  publisher = {Springer},
  keywords = {4DMRI, Statistical Modelling, Liver, Respiratory Motion}