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Glioblastoma growth modeling for radiotherapy target delineation.

J Unkelbach and B Menze and A Motamedi and F Dittmann and E Konukoglu and N Ayache and H Shi
Proc MICCAI Workshop on Image-Guidance and Multimodal Dose Planning in Radiation Therapy.
2012

Abstract

Radiotherapy treatment planning requires a localization of the tumor within the patient. This is challenging to accomplish for microscopic in ltrative spread of disease that is not visible on current imaging modalities. Prime examples for in ltrative tumors are gliomas. With the help of mathematical models, common growth characteristics of gliomas, which are known from histopathological studies, can be incorporated in radiotherapy target delineation. This requires an imaging based personalization of the model to the individual patient. We demonstrate use cases of the Fisher-Kolmogorov glioma growth model in radiotherapy planning of a clinical case. We further analyze the crucial input parameters to the model, in particular, the need for reliable segmentation of anatomical boundaries such as the falx cerebri and the tentorium cerebelli.


Link to publisher's page
@InProceedings{eth_biwi_00989,
  author = {J Unkelbach and B Menze and A Motamedi and F Dittmann and E Konukoglu and N Ayache and H Shi},
  title = {Glioblastoma growth modeling for radiotherapy target delineation. },
  booktitle = {Proc MICCAI Workshop on Image-Guidance and Multimodal Dose Planning in Radiation Therapy. },
  year = {2012},
  pages = {8},
  keywords = {}
}