FUSIMO - Patient specific modelling and simulation of focused ultrasound in moving organs

Objective:

The aim of FUSIMO is to develop, implement and validate a multi-level model for moving abdominal organs for use in magnetic resonance-guided focused ultrasound surgery.

In recent years, High-Intensity Focused Ultrasound and Focused Ultrasound (FUS) have become frequent tools for non-invasive benign tumour therapy. However, treating tumors with focused ultrasound is challenging in terms of reliable therapy planning, monitoring and outcome prediction especially in moving organs with a complex blood supply. It is important to understand that the processes involved in FUS therapy are multi-level ranging from organ morphology, perfusion and motion, down to microscopic and cellular level. The relation within and between these levels is not well understood.

In this project, a multi-level model for moving abdominal organs for use in magnetic resonance-guided focused ultrasound surgery will be developed. The overall model will consist of several sub-models, which interact and describe aspects in a hierarchical manner. The integrated model will consist of:
- Abdominal organ model to simulate motion and the influence on ultrasound application
- Target organ/tumour model to capture organ/tumour physiology, and organ/tumour reaction to therapy
- Microscopic tissue model to simulate direct heat ablation, model energy distribution, tissue heating and cooling
- Model to evaluate first steps to simulate drug delivery, microbubble distribution and dynamics

Participants: Prof. Gábor Székely, Dr. Christine Tanner, Dr. Golnoosh Samei

Partners:

Frauenhofer MEVIS, Germany,
University of Dundee, United Kingdom,
Technische Universiteit Delft, Netherlands
Stiftelsen SINTEF, Norway
Medical Imaging Research Institute, Germany
IBSmm Engineering spol. s r. o., Czech Republic
INSIGHTEC LTD, Israel
GEMS PET SYSTEMS AB, Sweden
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA, Italy
Eidgenössische Technische Hochschule Zürich, Switzerland
Fundatis Medis, Romania